Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
elifesciences.org
Finally, we found that paxillin enhances droplet formation even at low nanomolar concentrations of FAK and paxillin We conclude that interactions with paxillin enhance FAK phase separation. We conclude that kindlin enriches in droplets formed with the pCas mix through direct interactions with Cas th
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- Finally, we found that paxillin enhances droplet formation even at low nanomolar concentrations of FAK and paxillin
- We conclude that interactions with paxillin enhance FAK phase separation.
- We conclude that kindlin enriches in droplets formed with the pCas mix through direct interactions with Cas that do not require Cas phosphorylation
- β1 integrin weakly partitions into droplets formed with either the pCas mix or the FAK mix, but partitioning significantly increases when both pathways are combined to form droplets with the pCas + FAK mix
- We conclude that pCas- and FAK-driven phase separation synergistically promote integrin clustering on phospholipid bilayers.
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