Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM
elifesciences.org
suggests that most of the observed receptors were blocked from the ‘outside.’ possibly by increasing spermine permeation exclusively homomeric GluA1flip-containing combinations. However, given that NASPM was also uniformly effective in GluA2 KO CGCs, which are thought to express both flip and flop G
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- suggests that most of the observed receptors were blocked from the ‘outside.’
- possibly by increasing spermine permeation
- exclusively homomeric GluA1flip-containing combinations. However, given that NASPM was also uniformly effective in GluA2 KO CGCs, which are thought to express both flip and flop GluA4 splice forms
- varying degrees of R/G editing
- it seems unlikely that these posttranscriptional modifications influence the action of intracellular NASPM.
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