Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection
elifesciences.org
This circuit uses a two-signal mechanism to inactivate the PdtaS/PdtaR two-component system, which constitutively represses virulence gene expression. Cu and NO inhibit the PdtaS sensor kinase through a dicysteine motif in the N-terminal GAF domain. We have revealed a new branched pathway of signal
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- This circuit uses a two-signal mechanism to inactivate the PdtaS/PdtaR two-component system, which constitutively represses virulence gene expression. Cu and NO inhibit the PdtaS sensor kinase through a dicysteine motif in the N-terminal GAF domain.
- We have revealed a new branched pathway of signal transduction that integrates M. tuberculosis resistance to multiple host-derived stresses. M. tuberculosis is exposed to a mixture of toxic molecules within the host macrophage that include copper, zinc, and nitric oxide (Botella et al., 2011; Darwin, 2015; Darwin et al., 2003; Darwin and Nathan, 20...
- he true in vivo determinants of M. tuberculosis resistance to these molecules are unknown
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