The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila
elifesciences.org
We show that ESCRT and retromer functions are required for anterograde transport of SJ components Thus, Mega is moving along the apicobasal axis in CSC decorated vesicles. the classical retromer route involves cargo recycling in a detour via the Golgi. This is consistent with Vps35MH20 clones mainta
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- We show that ESCRT and retromer functions are required for anterograde transport of SJ components
- Thus, Mega is moving along the apicobasal axis in CSC decorated vesicles.
- the classical retromer route involves cargo recycling in a detour via the Golgi.
- This is consistent with Vps35MH20 clones maintaining intact apicobasal polarity and supports a role of retromer in trafficking specific structural components of SJs.
- Since the columnar wing imaginal disc cells have a very elongated shape and possess Golgi stacks all along the apicobasal axis, it is conceivable that certain Golgi stacks residing at the apical and basal poles are specialized in secreting apical and basolateral cargos, respectively.
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