The neural basis for a persistent internal state in Drosophila females
elifesciences.org
These data suggest that female pC1 neurons can drive an arousal state, similar to male P1 neurons Work on P1 in flies bears some similarity to work in mice. In male mice, optogenetic activation of SF1 (steroidogenic factor 1) expressing neurons in the dorsomedial part of the ventromedial hypothalamu
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- These data suggest that female pC1 neurons can drive an arousal state, similar to male P1 neurons
- Work on P1 in flies bears some similarity to work in mice. In male mice, optogenetic activation of SF1 (steroidogenic factor 1) expressing neurons in the dorsomedial part of the ventromedial hypothalamus (VMHdmSF1) drive multiple defensive behaviors that outlast the stimulation by up to 1 min
- In addition, activity of VMHdmSF1 neurons can persist for over a minute following the presentation of a fear stimulus
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