Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes thumbnail
Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes
elifesciences.org
We overestimated the number of genes that have undergone complete divergence by assuming that all genes in conserved micro-synteny regions share common ancestry. There are however limitations in using synteny to approximate common descent. First, with time, genome rearrangements shuffle genes around
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  • We overestimated the number of genes that have undergone complete divergence by assuming that all genes in conserved micro-synteny regions share common ancestry. There are however limitations in using synteny to approximate common descent. First, with time, genome rearrangements shuffle genes around and synteny is lost. This means that when compari...
  • Here, we harness the special circumstance of conserved synteny to estimate the contribution of complete divergence to the pool of orphan genes.

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