Large and fast human pyramidal neurons associate with intelligence
elifesciences.org
individuals with higher IQ scores sustain fast action potential kinetics during repeated firing To test this, we made whole-cell recordings from pyramidal cells in acute slices of temporal cortex (31 subjects, 129 neurons, median number of neurons per subject = 3; ranging from 1 to 11 Figure 5) and
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- individuals with higher IQ scores sustain fast action potential kinetics during repeated firing
- To test this, we made whole-cell recordings from pyramidal cells in acute slices of temporal cortex (31 subjects, 129 neurons, median number of neurons per subject = 3; ranging from 1 to 11 Figure 5) and recorded APs at different firing frequencies in response to depolarizing current steps.
- test whether AP rise speed differed between IQ groups, we split all AP rise speed data into two groups based on IQ score – above and below 100.
- the AP slowed down stronger in individuals with lower IQ scores compared to APs of individuals with higher IQ scores
- At higher instantaneous firing frequencies (20–40 Hz), the AP rise speed was higher in individuals with IQ scores above 100
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