PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
elifesciences.org
Moreover, there is a considerable lack in understanding of the chromatin changes associated with enhancer activation that leads to lineage-specific gene transcription during differentiation of mesenchymal stem cells. However, in MSCs, PLZF is expressed only in differentiating MSCs and not in naive c
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- Moreover, there is a considerable lack in understanding of the chromatin changes associated with enhancer activation that leads to lineage-specific gene transcription during differentiation of mesenchymal stem cells.
- However, in MSCs, PLZF is expressed only in differentiating MSCs and not in naive cells (stem cells), and its molecular function is so far unknown in these cells.
- Observing earlier timepoints, we found that the expression of ZBTB16 was strongly induced (≥ 4000 fold analyzed by QPCR) already at day 2 of differentiation which corresponds to pre-osteoblasts.
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