A first order phase transition mechanism underlies protein aggregation in mammalian cells
elifesciences.org
Classical nucleation theory considers a simple question: Given a collection of molecules, if a subset of the molecules cluster together, would this raise or lower the energy of the system. The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble. W
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- Classical nucleation theory considers a simple question: Given a collection of molecules, if a subset of the molecules cluster together, would this raise or lower the energy of the system.
- The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble.
- We find that even under normal growth conditions mammalian cells have precursor clusters
- or a so-called super-saturated system in first order phase transition.
- in this disassembly of large clusters. The results indicate early aggregates behave like condensates.
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