A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms
elifesciences.org
Now it emerges that expression of Zfh-1 identifies a population of muscle-associated cells in the adult that retain progenitor-like properties Drosophila notably differs because their satellite-like cells do not express the Pax3/Pax7 homologue (gooseberry; data not shown), considered a canonical mar
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- Now it emerges that expression of Zfh-1 identifies a population of muscle-associated cells in the adult that retain progenitor-like properties
- Drosophila notably differs because their satellite-like cells do not express the Pax3/Pax7 homologue (gooseberry; data not shown), considered a canonical marker in mammals and some other organisms (Chang and Rudnicki, 2014).
- Nor do they express the promyogenic bHLH protein Twist (data not shown), which is present in the muscle progenitors in the embryo
- The concept that signaling can differentially regulate RNA sub-types has so far been little explored but our results suggest that is potentially of considerable significance.
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