Top Highlights

• First, how multiple cells interact to recapitulate organ architecture. Second, what is the mechanism that controls the correct reproduction of cell number and localization
• We find that interneuromast cells are not essential for neuromast regeneration because severely damaged organs recover all cell classes in the appropriate localization in the absence of interneuromast cells. However, we systematically observed smaller organs when interneuromast cells where ablated. These observations suggest that these peripheral c...
• Despite the intrinsically stochastic nature of damage, sensory organs recapitulate normal architecture during repair to maintain function. Here we present a quantitative approach that combines live cell-lineage tracing and multifactorial classification by machine learning to reveal how cell identity and localization are coordinated during organ reg...
• sensory organs recapitulate normal architecture during repair to maintain function
• quantitative approach that combines live cell-lineage tracing and multifactorial classification by machine learning to reveal how cell identity and localization are coordinated during organ regeneration

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