Control of AMPA receptor activity by the extracellular loops of auxiliary proteins
elifesciences.org
TARPs and other auxiliary proteins modify the gating and pharmacology of synaptic AMPA receptors effects of auxiliary proteins on receptor gating were due to the extracellular domains modulate gating and conductance of GluA receptors transmembrane interactions are important for proper assembly, with
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- TARPs and other auxiliary proteins modify the gating and pharmacology of synaptic AMPA receptors
- effects of auxiliary proteins on receptor gating were due to the extracellular domains
- modulate gating and conductance of GluA receptors
- transmembrane interactions are important for proper assembly, with the TM3 and TM4 segments of γ2 and the M1-M3 helices of the AMPA receptor determining complex assembly
- C-termini of both the AMPA receptor and TARPs also appear to be involved
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