TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
elifesciences.org
We next used species-specific shRNA lentiviral vectors to suppress TRIM28 expression in human cells, in mouse primary cerebellar neurons, and in mouse hippocampus (Figure 1C and Figure 1—figure supplement 3A,B). In each case, partial reduction of TRIM28 led to a decrease of both α-Syn and tau, and v
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- We next used species-specific shRNA lentiviral vectors to suppress TRIM28 expression in human cells, in mouse primary cerebellar neurons, and in mouse hippocampus (Figure 1C and Figure 1—figure supplement 3A,B). In each case, partial reduction of TRIM28 led to a decrease of both α-Syn and tau, and virally reintroducing a human shRNA-resistant TRIM2...
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