The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
elifesciences.org
Previous experiments on transgenic mice with high levels of this hormone have shown that it suppresses the activity of growth hormone and reduces the production of insulin-like growth factor, which prevents growth and can lead to hibernation-like behavior we examined whether chronic FGF21 exposure m
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- Previous experiments on transgenic mice with high levels of this hormone have shown that it suppresses the activity of growth hormone and reduces the production of insulin-like growth factor, which prevents growth and can lead to hibernation-like behavior
- we examined whether chronic FGF21 exposure mimics nutrient deprivation with respect to changes in gene expression
- transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling
- FGF21 is not an endogenous mediator of the caloric restriction response
- FGF21 may extend lifespan by regulating a small subset of genes also regulated by caloric restriction in liver
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