Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study thumbnail
Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study
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Chronic nicotine exposure was reported to reduce the sensitivity of GABA receptors and result in disinhibition of midbrain dopamine neurons (Amantea and Bowery, 2004). Chronic nicotine administration was also reported to increase the level of ionotropic glutamate receptors in the midbrain and concei
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  • Chronic nicotine exposure was reported to reduce the sensitivity of GABA receptors and result in disinhibition of midbrain dopamine neurons (Amantea and Bowery, 2004). Chronic nicotine administration was also reported to increase the level of ionotropic glutamate receptors in the midbrain and conceivably enhance the excitatory input to the midbrain
  • Enhanced striatal dopamine release in smokers might be a consequence of altered control of dopamine release after repeated nicotine exposure.

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