Top Highlights

• The first is the insular cortex, which is specialised for interoceptive awareness and is widely claimed to generate the feelings that constitute a sentient ‘self’.30 The second is the dorsolateral prefrontal cortex, which forms a superstructure over all other parts of the brain, and is generally believed to enable ‘higher-order thoughts’, including...
• Now you see how closely affects are tied to drives; they are their subjective manifestation.
• The second thing to notice about feelings is that they are always conscious.
• Conscious thinking requires cortex. But the feelings that guide it do not. The circuit mediating RAGE is almost entirely subcortical, and, like all the other affective circuits, its final destination is the brainstem PAG.14
• First, it reduced positive psychotic symptoms